Myocardial Infarction (MI) is one of the most common heart diseases. Health learning instructions can improve the therapeutic regimen compliance and self-efficacy among patients with MI. Self-efficacy is an individual’s confidence in one’s ability to manage disease. The aim of this study was to evaluate the effect of learning instructional on therapeutic regimen compliance and self-efficacy among patients with MI. Research design: A quasi experimental research design was used. Setting: The study was conducted at outpatient cardiac clinics at Zagazig University Hospitals. The study sample composed of fifty adult patients, purposeful selected from both sexes. Tools: Four Tools were used for data collection, pertinent as follow: Patient interviewing assessment questionnaire, an observational checklist, Patients' compliance assessment Questionnaire and Chronic disease Self- Efficacy Scale. Results: revealed that, Majority of the studied patients were male, 62% aged from53 to 63 years and 72% having co-morbid disease mainly hypertension and diabetes mellitus. There were statistically significant improvements in patients’ knowledge, practice, therapeutic regimen compliance and self-efficacy post intervention phase. Conclusion: The learning instructional had a positive effect on improving therapeutic regimen compliance and self-efficacy among studied patients with MI through the enhancement of their knowledge and practices. Recommendations: Regular follow - up for all patients with MI to evaluate their health conditions and detect the complications early.