Blood is a unique and scarce resource that must be used cautiously to ensure its safety and efficacy. Blood transfusion is a lifesaving medical intervention, but without basic information about each step, the importance of each one related to each other, and when safe practices are not followed, transfusion of blood can create life-threatening risks. The nursing team has a dynamic role in blood transfusion procedures; their skills and knowledge remain essential keys to ensuring safe blood transfusion. Study aim: evaluate the effect of the educational bundle on securing nursing competency toward safe blood transfusion. Study Design: a quasi-experimental design. Setting: blood disorders, emergency, and oncology departments at Zagazig University Hospitals, Al Sharkia Governorate, Egypt. Subject: all available nurses (50) who are working in the previously mentioned settings. Tools: A structured interview questionnaire to assess nurses' socio-demographic characteristics and their knowledge about the safe blood transfusion process; and a blood transfusion observational checklist were used to collect data. Results: the highest percentage of participant nurses their age was 25-30 years and had ≤5 experience years in blood transfusion. There were a statistically significant difference and improvement in the total nurses' knowledge and their practice competency toward safe blood transfusion after educational bundle implementation compared to before it, and there was a positive statistically significant correlation between total nurses' knowledge and practice regarding safe blood transfusion pre and post-implementation of the educational bundle. Moreover, the commonest errors in the blood transfusion process that lead to an adverse reaction as reported by participants' nurses included blood incompatibility followed by not checking vital signs pre, during, and post-transfusion. Conclusions: The implementation of the educational bundle had a positive effect in improving nurses' knowledge and practice competency towards blood transfusion, ensuring that it is performed safely. Recommendations: continually perform regular in-service training and follow-up to nurses' performance and motivation to update their knowledge and practices.