Background: Inflammatory bowel disease (IBD) has been a global healthcare problem with a sustained increasing incidence. The evaluation of the inflammatory activity and prediction of relapses are essential for individual therapy and for patients encouragement for better disease care. The ultimate goal in IBD is to restore disease remission as early as possible and to prevent disease progression and resistance to pharmacotherapies. Aim of the work: This study aims to restore disease remission and predict relapses as early as possible to prevent disease progression and also aims to decrease work disabilities and social and economic burdens of the disease on the community