The aim of the research was to evaluate the efficacy of safety measures and discharge planning guidelines on nurses for enteral nutrition of comatose patients. Research Design: Quasi-experimental design has been used to assess the impact of tailored intervention guidelines on the understanding and performance of nurses and to attain the research objectives. Setting: The research was carried out at Benha and Zagazig University Hospitals ' intensive care units. Sample: 60 Sample of convenience chosen from the accessible nurses working in Benha and Zagazig University Hospitals ' intensive care units. Tools: two developed tools were used, The first tool was the interview questionnaire for nurses, which covered two parts: Part 1: demographic data for nurses (age, education level, years of experience and marital status); Part 2: questionnaire sheet for assessing nurses ' understanding of safety measures during enteral nutrition delivery and the design of the discharge plan. The second tool: an observational checklist to evaluate: the practice of nurses in implementing the safety measure and the execution of the discharge plan during enteral nutrition. Results: The findings of the research showed that: more than three-quarters of nurses (88.3 per cent) had inadequate understanding prior to the completing of the guidelines. On the other side, after the guidelines were implemented, more than two-thirds (75%) of nurses had a strong degree of understanding. More than half of nurses (55%) also had a decent degree of understanding after two months of application. Before the guidelines were implemented, more than three-quarters of staff (83.3%) had an unsatisfactory amount of exercise. However, the bulk of nurses (78.3 percent) had a level of excellent practice compared to pre-intervention after the instructions were applied. After two months of applying the guidelines, the significant statistical correlation coefficient was found at p-values < 0,001 between the knowledge, practice and specific demographic data of nurses. Conclusion: The study concluded that there was a statistically significant improvement in the overall knowledge and practice of nurses in the application of safety measures during enteral nutrition, in particular following guidelines. Recommendations: Based on the outcomes of the research, we suggested that: ongoing safety measure training should be implemented to refresh the understanding of nurses by providing enteral nutrition to comatose patients. In addition, he stressed how to develop a comatose discharge plan as part of safety measures in the training of nurses.