Losartan prevents methotrexate-induced liver and lung injury in rats via targeting PPAR-γ/TGF-β1/SMAD3 and Nrf2/redox signaling

Faculty Medicine Year: 2023
Type of Publication: ZU Hosted Pages: 135-148
Authors:
Shereen Samy Mahmoud Osman
Journal: Zagazig University Medical Journal (ZUMJ) Faculty of Medicine, Zagazig University Volume: 29
Keywords : Losartan prevents methotrexate-induced liver , lung injury    
Abstract:
Background: Despite high efficacy-to-toxicity ratio of chemotherapeutic agent, methotrexate, toxicity remains a major concern that limits its use. Inflammatory, oxidative stress and fibrotic pathways are implicated in methotrexate-induced i
    
     
 
       

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