Losartan prevents methotrexate-induced liver and lung injury in rats via targeting PPAR-γ/TGF-β1/SMAD3 and Nrf2/redox signaling

Faculty Medicine Year: 2023
Type of Publication: ZU Hosted Pages: 135-148
Authors:
Shereen Samy Mahmoud Osman
Journal: Zagazig University Medical Journal (ZUMJ) Faculty of Medicine, Zagazig University Volume: 29
Keywords : Losartan prevents methotrexate-induced liver , lung injury    
Abstract:
Background: Despite high efficacy-to-toxicity ratio of chemotherapeutic agent, methotrexate, toxicity remains a major concern that limits its use. Inflammatory, oxidative stress and fibrotic pathways are implicated in methotrexate-induced i
    
     
 
       

Author Related Publications

  • Shereen Samy Mahmoud Osman, "Synthesis, In vivo and In silico Evaluation of Novel 2,3-Dihydroquinazolin-4(1H)-one Derivatives as Potential Anticonvulsant Agents", wiley, 2019 More
  • Shereen Samy Mahmoud Osman, "Possible Protective Effects of Propranolol and Carvedilol and Their Interaction with Mesalazine on Experimentally Induced Ulcerative Colitis in Male Albino Rats", 2024 More
  • Shereen Samy Mahmoud Osman, "PROTECTIVE EFFECTS OF IVABRADINE (ALONE AND COMBINED WITH ATENOLOL OR ENALAPRIL) ON EXPERIMENTALLY-INDUCED ACUTE MYOCARDIAL INFARCTION IN ALBINO RATS", Zagazig University, 2017 More
  • Shereen Samy Mahmoud Osman, "Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1/RAGE/NF-κB/JNK pathway and endoplasmic reticulum stress", nature publishing group, 2023 More
  • Shereen Samy Mahmoud Osman, "Diacerein ameliorates cholestasis‑induced liver fibrosis in rat via modulating HMGB1/RAGE/NF‑κB/JNK pathway and endoplasmic reticulum stress", Springer Nature, 2023 More

Department Related Publications

  • Ibtesam Abdelaal Ahmd, "• Role of ATP sensitive potassium channels in contractility of isolated gall bladder from Guinea Pig.", لايوجد, 1900 More
  • Sohir Hanem Samir Mahmoud Elmenshawy, "12- خاصية انتقاء عقار البينافريم بروميد للعمل على الجهاز الهضمي.", لايوجد, 1900 More
  • Sohir Hanem Samir Mahmoud Elmenshawy, "11- تأثير الديبروبيلين على بعض العضلات الملساء لحيوانات التجارب مع دراسة مقارنة مع الهيوسين بيوتيل بروميد والبابافيرين.", لايوجد, 1900 More
  • Sohir Hanem Samir Mahmoud Elmenshawy, "13- دراسة مقارنة الجمع لسمية عقاري الكونيدين والكلوميبران على الفئران البيضاء.", لايوجد, 1900 More
  • Nabila Mustafa Kamal Hassan Abadi, "Skeletal muscle relaxant effect of Propofol ", لايوجد, 1900 More
Tweet