Abstract Purpose: The aim of this study was to evaluate the effect of argon laser photocoagulation on xanthelasma using ImageJ software. Patients and methods: The study included 41 eyes of 23 patients (49 individual xanthelasmic lesions). All lesions were treated by a single session of argon laser photocoagulation. The lesions were assessed prelaser and postlaser using ImageJ software. Results: All xanthelasmic lesions improved in height and color. The pretreatment mean height in ImageJ was 168.93±11.64 pixels, while the mean posttreatment height was 131±8.39 pixels (P<0.001). The color moderately improved in 24.4% of the cases and markedly improved in 68.3% of the cases. Conclusion:Argon laser treatment of xanthelasma is a safe and effective treatment modality. This finding was documented using ImageJ software