Background: Both iron deficiency anemia (IDA) and dyslipidemia are widely prevalent public health problems, especially in the Egyptian population. So, the purpose of this research was to study the correlation between dyslipidemia and IDA in Egyptian adults, Minoufiya Governorate population. Methods: In this comparative cross-sectional study, 110 adult with confirmed IDA and 110 healthy controls, in the age group 18-55 years were investigated for any possible changes in serum lipid profile i.e., triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c). Also, correlation between serum lipid profile and severity of anemia was also calculated. Results: The results are shown as mean± standard deviation. TG, TC, LDL-c and VLDL-c levels were found to be significantly (P <0.001) elevated in the IDA group (were 85.67±26.86, 123.79±30.54, 71.57±24.64 and 17.13±7.21 mg/dl) as compared to controls (107.89±22.40,158.45±26.34, 93.24±18.45 and 21.58±5.76 mg/dl). whereas level of HDL-c were found to be significantly (P <0.001) higher in patients (43.63±12.54 mg/dl) as compared to controls (35.09±13.05mg/dl). Correlation between lipid profile (TG, TC, and LDL) levels and severity of anemia (hemoglobin levels) showed positive and significant (P <0.01) values. Conclusion: These findings indicate that that the levels of serum lipid profile in Egyptian adults IDA were lower than the healthy control. However, to identify potential mechanisms of this relationship, further research are recommended to be carried out.