With the humongous boom in the human population with in the last 100 years, there has been an parallel increase in the rate of climate change and prevalence of unfavorable environmental conditions around the globe. These conditions impose stress on the crop plants leading to a huge economic loss of yield. To survive under these stressful conditions, the most prominent way is the endogenous production of various phytohormones. Upon production, these phytohormones exhibit their response by modulating signaling pathways at physiological, biochemical, and molecular levels. They pertain these stresses by controlling the expression of various genes, small RNAs, and transcription factors to mitigate the adverse effect of the stress. Interestingly, Jasmonic acid (JA), a class of polyunsaturated fatty acid-derivative is one such phytohormone that can regulate plant growth and response towards different environmental stresses through interaction with other phytohormones. Various regulatory transcription factors and related genes play a central role in the JA signaling pathway in response to abiotic stresses. For resisting harsh environmental conditions, JA can work both synergistically and antagonistically with different phytohormones. Therefore, this current chapter focuses on the contribution of JAs in plant protection from the various biotic and abiotic stresses and their interaction with different plant hormones.