Introduction and significance of the study: Chronic kidney disease (CKD) is the major health problem worldwide defined as the presence of kidney damage, either structural or functional, or a decrease in glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 of body surface area for more than 3 months. Therefor Children with CKD require complex medication schedules, dietary restrictions, and invasive procedures such as three times weekly hemodialysis or daily nocturnal peritoneal dialysis. Children with CKD are at a higher risk of severe clinical manifestations of COVID-19. They require maintenance hemodialysis (HD) and are at risk of infection because they are malnourished and has low immunity. Support and information are required to help these children cope with the difficulties they face throughout all stages of CKD. Educating children is very important to improve their practices and the consequences of QOL. Advances in technology, such as the use of mobile in medical care for children with CKD who have a high chance of survival improve QOL as it helps children with chronic kidney disease better manage their disease and related conditions, and 85% to 90% of patients have access to mobile health technology. Aim: The study aimed to evaluate the effect of using mobile based health - education on the quality of life among children with chronic kidney diseases during COVID-19 Pandemic. Subjects and Methods: Research design: A quasi-experimental design (one group pre/post - test) was utilized. Setting: The study was conducted in the Pediatric Nephrology and Dialysis Unit and the Outpatient clinic of pediatric nephrology at Mansoura University Hospital. Subjects: A purposive sample of 50 children suffering from chronic kidney diseases was selected. The subjects were used as pre intervention and post intervention group (the same group used as a control and study group). Data collection Tools: Two tools were used: Tool (I) :-Interviewing questionnaire for children with chronic kidney diseases and Tool (II) The Arabic PedsQL Inventory is used to assess the children’s quality of life (PedsQL) 4.0 Generic Core Scales (GCS). Results: The present study revealed that the mean age of studied children was 10.9 ± 2.1years old, near two-thirds (63.2%) were males. Most of the studied children (84%) were from rural. 67% of children had a poor level of knowledge regarding CKD pre mobile health education implementation as compared to 4% post mobile health education implementation, While, 90% of them had a good level of knowledge post intervention as compared to 4% pre intervention and there was a statistical significant difference regarding to the total knowledge of studied children pre and post mobile health education (P<0.05). The mean scores of all quality of life domains of children with CKD in physical, emotional, social, and school domains (64.7 ± 16, 75.9 ± 17.1, 84 ± 9.1, and 57 ± 14.7 respectively) were a high rate of quality of life post-implementation of the mobile health education, compared to pre mobile health education (56.5 ± 18.5, 64.2 ± 24.5, 61.6 ± 29.4, 46.1 ± 24.3 respectively). A highly statistically significant difference was found between total mean scores of all quality of life domains pre-and post- mobile health education implementation with a p-value (<0.01). Conclusion: Based on the findings of the current study's aim and hypotheses, the current study concluded that mobile based health education was effective in improving knowledge among children with CKD after the implementation. Mobile based health education had a statistical significant difference on improving the quality of life of children with chronic kidney diseases. Recommendations: The study recommended that Mobile based health education can be integrated to home care and follow up for children with CKD at the health care settings.