Prevalence of onychomycosis among exposed workers was 24.6% versus 3.3% among controls (general population) (P<0.001), 75% of exposed workers had multiple fingernails OM, 50% of them was candida onychomycosis (CO) and 31.3% proximal subungual onychomycosis (PSO), while the two cases of controls had single toenail distal and lateral subungual onychomycosis (DLSO). old age found to be significant among onychomycosis (OM) cases, all OM cases involved in wool fibers washing and processing (56.3%) or yarn dying (43.7%) versus 8.2% and 10.2% respectively of non-infected group. Among the statistically significant risk factors observed, extended hand immersion in water accounted for 62.5% of cases, prior treatment history accounted for 31.3% of cases, and exposure to irritating chemicals and detergents accounted for 37.5% of cases. Conclusions: Onychomycosis is a common health problem among carpet weaving workers, especially manual workers due to wet processes and exposure to chemical dyes without using PPE, so protective measure should be taken after treatment of the problem.