F18 fluoro-deoxy-glucose positron emission tomography/computed tomography (F18-FDG-PET/CT) now is the gold standard imaging for the initial assessment of lymphoma. The most commonly used parameter for the assessment of the activity is the maximum standardized uptake value (SUV max). Metabolic tumor value (MTV) and total lesion glycolysis (TLG) are other metabolic PET/CT parameters that assess the size of a lesion and behavior. In this study, we analyzed the data extracted from a PET/CT study done for initial assessment, to know if there is a difference in the metabolic parameters (SUV max, MTV, and TLG) of the most active lesion between the two main pathological types of lymphoma. Patients and Methods This study included 73 lymphoma patients, all of whom had undergone F18-FDG PET/CT as an initial assessment. The images of these patients were interpreted by two experienced nuclear medicine specialists. First, visual assessment was done to detect the presence of any extra-nodal lesions, the distribution of the positive LN groups, and the distribution of the most active lesion Semi-quantitative parameters were calculated using three dimensional volume of interest (VOI) around the most active lesion either nodal or extra-nodal (SUV max, MTV, and TLG) to detect if there is any statistically significant difference between Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Results Of the 73 patients included in this study, 40 patients had HL and 33 patients had NHL. There was a significant difference in presence of the extra-nodal lesions, distribution of nodal lesions, and the distribution of most active lesions between the two groups (P-value 0.017 and 0.04 respectively). There were no statistically significant differences between the 2 main groups (HL and NHL) regarding SUV max, TLG, and MTV (p-values were 0.339, 0.19, 0.333 respectively). Conclusion: Our study finds that the presence of the extra-nodal lesions, distribution of nodal lesions, and the distribution of most active lesions have a significant difference between HL and NHL, but metabolic parameters (SUV max, TLG, and MTV) have no significant differences between the two groups. Keywords F18 -FDG PET/CT, initial lymphoma, metabolic parameters, SUV max, TLG, MTV