Ginger is used to relief the symptoms of gastrointestinal upsets associate with motion sickness, surgery and pregnancy. cyclosporine has immune-suppressive properties and used in treatment of diseases with auto immune mechanisms. It has anti-oxidant, anti-arthritic and anti-hepatic toxicity. The most serious side effect of cyclosporine is its hepato-toxicity and the significant rise in serum creatinine. This renal affection includes both glomerular and tubular damage with renal damage. Aim of work: The aim of this work is to find out the possible protective role of Ginger in renal protection against cyclosporine nephro-toxicity. Materials and methods: Sixty male albino rats were used and divided into three groups; Group I (control): including 20 rats given olive oil in a dose of 0.5 ml once every day for 35 days as subcutaneous injection, Group II: including 20 rats injected subcutaneously daily for 35 days by cyclosporine (15mg /kg body weight) and Group III: including 20 rats were given the same dose of cyclosporine as in group II followed by 1ml of final aqueous extract of ginger (24 mg/ml) once daily for 35 days. The animals were anaesthetized , the abdomen was incised and the extracted kidneys were processed for both light and electron microscopic study. Results: Cyclosporine produces atrophy and degeneration of the glomeruli. The glomeruli showed marked decrease in the cellularity of blood capillaries, rupture of the renal capillaries and extravasations of blood with dilatation of the bowman's space. It produces also degeneration and atrophy of the renal convoluted tubules with marked disarrangement of their cells and vacoulations in their cytoplasm. The renal cortex showed areas of focal thickening of the glomerular basement and obliterated endothelial fenestrations and focal foot processes fusion of podocytes. The mitochondria appeared swollen and the brush border of epithelial cells was markedly lost and destructed Ginger treatment with Cyclosporine produce recovery of the glomeruli nd renal tubules. The renal cortex of this group showed normal glomerular structure, the podocytes appeared normal with their processes intact and closely adherent to the glumerular capillaries with the filtration sites appear normal with fenestrated endothelial lining.