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C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients.
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Mohamed Mohyldeen
Staff Zu Site
Abstract In Staff Site
Journal:
Modern Rheumatology Journal Ima-Press Publishing House, Moscow
Volume:
2
Keywords :
C-Reactive Protein to Albumin Ratio , Albumin , Fibrinogen
Abstract:
Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA. Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment. Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients. Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity.
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Amany Mohamed Mohyldeen, "Designing an autoverification system in Zagazig University Hospitals Laboratories: Preliminary evaluation on thyroid function profile", King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia., 2014
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Amany Mohamed Mohyldeen, "Role of Vitamin D Deficiency in Coronary Artery Disease and Cardiac Dysfunction", SCIENCEDOMAIN, 2016
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Amany Mohamed Mohyldeen, "Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis", Taylor&Francis Group, 2017
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