UV AND UV DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF 2-COMPONENT MIXTURES

In this paper, two-component mixtures (spironolactone with hydrochlorothiazide, captopril with hydrochlorothiazide, and spironolactone with furosemide) were assayed by U.V. (A), first derivative (dA/d-lambda) and second derivative (d2A/d-lambda-2) spectrophotometric methods, applying ``Zero-Crossing{''} technique of measurement. The methods were proved using laboratory prepared mixtures. The utility of the methods in assay of dosage forms is also presented.