The kidney plays a vital role in eliminating the toxic substances and drug metabolites from blood. Therefore, it is prone to hazards in case of abuse or overdose of drugs. The aim of the work was to clarify the impact of Moringa oleifera (MO) against the nephrotoxic effect of paracetamol in adult male albino rats. Twenty-eight adult male albino rats were used in this study and divided equally into four groups (G); G1 (control G), G2 (paracetamol- treated animals), G3 (paracetamol- plus high MO- treated G), G4 (high MO-treated rats). Kidney specimens were harvested after anesthetizing the animals, and then processed for histological and DNA comet analysis. Biochemical blood investiga- tions for kidney function were also performed through assessment of serum creatinine (Cr) and blood urea nitrogen (BUN). Administration of para- cetamol resulted in genotoxicity and marked bio- chemical and renal histological changes. It caused a significant increase in Cr and BUN levels and degeneration in both proximal and distal convolut- ed tubules with glomerular changes. Administra- tion of MO with paracetamol led to a noticeable amelioration of previous mentioned changes. Moringa oleifera is suggested to be an effective nephroprotection against paracetamol-induced damage. Further studies are recommended to con- firm the protective role of MO using large numbers of different animal models before investigating it in humans.