Background: Psoriatic arthritis (PsA) which afects 6–42% of psoriasis patients is the most common extra-cutaneous manifestation of the psoriasis disease. Enthesitis may be considered as a sign of increased disease burden due to its association with several clinical aspects. Therefore, the aim of the study was to investigate the efect of clinical enthesitis on quality of life and work productivity in PsA patients. Results: Enthesitis was detected in 50% of patients. There was statistically signifcant diference between the studied groups as regard disease activity index for psoriatic arthritis (DAPSA) score, psoriatic arthritis impact of the disease 12 (PsAID-12), Health Assessment Questionnaire disability index (HAQ-DI), and Spondyloarthritis Research Consortium of Canada index (SPARCC) with higher mean score in patients with enthesitis. The majority of patients with enthesitis had a higher percentage of impairment in daily activities (95.5%) than those without enthesitis (38.6%), as well as a statistically signifcant positive correlation between SPARCC index and both work absenteeism and work productivity loss. Furthermore, enthesitis in both the upper and lower sites was related with worse quality of life (36.4%) and higher work impairment (45.5%) compared to patients with enthesitis in either the upper or lower sites alone. Conclusion: Enthesitis was a frequent complaint among PsA patients. PsA patients with enthesitis had a signifcant disease burden regardless of enthesitis location, and patients with enthesitis in both the upper and lower sites have a worse quality of life and a higher work impairment. © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Background Psoriatic arthritis (PsA) is a chronic infammatory disease that afects up to 1% of the population [1]. It is a complex disease involving musculoskeletal disorders (related to the spine, enthesis, and peripheral joints) as well as extraarticular extra-cutaneous manifestations such as gastrointestinal and eye manifestations [2]. PsA, which afects 6–42% of psoriasis patients, is the most common extracutaneous manifestation of the disease [3]. Enthesitis, defned as the infammation of the junction where the tendon, ligament, or joint capsule inserts into the bone [4], has been related to axial and per