Globalization and the rapid growth of technologies are the main challenges facing the manufacturer and its sustainability and survival. Sustainability for any manufacturing plays an important role in competitive advantage which make the manufacturing firm a sustainable competitor. Sustainability in manufacturing is integrated with Industry 4.0 (I4.0) to achieve benefits of economic, environmental, and social. But it has many criteria and factors and contains incomplete and uncertain information. So, we used the neutrosophic sets to overcome this incomplete information and treat with uncertainty environment. The Single-Valued Neutrosophic Set (SVNS) is used to evaluate these criteria, which include three values (Truth, indeterminacy, and falsity). The SVNS is integrated with Multi-Criteria Decision Making (MCDM) methods. The MCDM concept is used in this paper to deal with many conflicting criteria. A Decision-making trial and evaluation laboratory (DEMATEL) is utilized for determining the relation between five main criteria and fourteen sub-criteria in this study. Analytic Hierarchy Process (AHP) is used to compute the weights of the main and sub-criteria. Our framework is applied to a real case study in Egypt to show the validity of our framework