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Evaluation of QT Intervals in Compensated and Decompensated Chronic Hepatitis C Cirrhotic Patients
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Ashraf Khaliefa Ashraf Elnagar
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Hospital Medicine The Egyptian Journal of Hospital Medicine
Volume:
Keywords :
Evaluation , , Intervals , Compensated , Decompensated Chronic Hepatitis
Abstract:
Evaluation of QT Intervals in Compensated and Decompensated Chronic Hepatitis C Cirrhotic Patients Background and Aim: Cirrhotic cardiomyopathy is chronic cardiac dysfunction in cirrhotic patients with no previous structural heart disease. QT prolongation is one of the most important cardiac alterations related to cirrhosis. This study was aimed to evaluate QT interval duration among compensated and decompensated chronic Hepatitis C (Ch HCV) cirrhotic patients and to detect its relation to biochemical changes in cirrhosis and its effect on patients’ outcome. Patients and Methods: A cross sectional study was conducted on 52 Ch HCV patients divided into two groups according to presence of signs of decompensation. Patients underwent clinical, laboratory and electrocardiographic evaluation. Cirrhosis severity was classified according to the Child-Pugh score. The QT interval in lead II (QTII), maximum QT (QTmax), heart rate corrected QTmax (msillisecond) obtained manually using by a 12-lead electrocardiogram. Results: Decompensated patients had non-significantly lower values of QTII and QT max. There was significant difference between both groups regarding QT maxc. 80.8% versus 38.5% of decompensated and compensated patients had prolonged QTC. There was significant relation between child class and QT parameters. There was significant relation between QT maxc prolongation and serum Albumin, sodium, ammonia, Urea, AFP and APACHE-II. There was significant relation between outcome and both QT max and QT maxc. Cutoff of QT max n predicting mortality was≥435 with sensitivity 80% and specificity 69%. QT maxc cutoff ≥508 predicted mortality with sensitivity 80% and specificity 84%. Conclusion: A prolonged QT maxc was prevalent among cirrhotic patients and this positively correlated with disease severity and high mortality. .
Author Related Publications
Ashraf Khaliefa Ashraf Elnagar, "Assessment of Advanced Glycation Endproducts in Offspring of Type 2 Diabetes", International Journal of Science and Research (IJSR) , Volume 4 Issue 12, 781-788, December 2015, 2015
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Ashraf Khaliefa Ashraf Elnagar, "Evaluation of Thyroid Dysfunction in Patients with Chronic Obstructive Pulmonary Disease in Medical Intensive Care Unit of Zagazig University Hospitals", International Journal of Advanced Research , Volume 4, Issue 1, January 2016, 270 – 281, 2016
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Ashraf Khaliefa Ashraf Elnagar, "Circulating Serum Irisin Levels in Obesity and Type 2 Diabetes Mellitus", international union of biochemistry and molecular biology, 2016
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Ashraf Khaliefa Ashraf Elnagar, "Serum Kidney Injury Molecule-1 in Hepatorenal Syndrome at Medical Intensive Care Unit of Zagazig University Hospitals", : International Journal of Science and Research (IJSR) Volume 5 Issue 7, 1539-1544, July, 2016, 2016
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Ashraf Khaliefa Ashraf Elnagar, "Assessment of Mean Platelet Volume in Patients with Acute Coronary Syndrome", Medical Journal of Cairo University, June 2016, 2016
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Department Related Publications
Ayman Riad AbdulHameed Elsayed, "Risk of acute kidney injury in patients with acute respiratory distress syndrome and its effect on the outcome", Wolters Kluwer - Medknow, 2020
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Emad Fawzy Hamed Mahmoud, "Non-specific colitis among patients with colitis: Frequency and relation to inflammatory bowel disease, a prospective study", Sociedade Brasileira de Coloproctologia, 2019
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Amro Shaban Hanafy Elsayed, "Management of HCV‑related decompensated cirrhosis with direct‑acting antiviral agents: who should be treated?", springer, 2019
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Khalid Ahmed Mohammed Al-Banna, "Serum Pentraxin 3 level as a recent biomarker of diabetic retinopathy in Egyptian patients with diabetes", Elsevier Ltd, 2019
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Salama Alsayed Farag Ghareeb, "Chemerin : A Biomarker for Cardiovascular Disease in Diabetic Chronic Kindey Disease Patients", online journal, 2016
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