Heterocyclization of Aromatic Amino Acids: Novel Syntheses and Antibacterial Activity of Fused, Non-fused, and Spiro Polyheterocyclic Derivatives

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Russian Journal of Organic Chemistry United States Pleiades Publishing Volume:
Keywords : Heterocyclization , Aromatic Amino Acids: Novel Syntheses    
Abstract:
Commercially available p-aminobenzoic acid was used as a precursor for the synthesis of novel fused, non-fused, and spiro polyheterocyclic derivatives bearing indene, imidazole, pyrazole, and/or triazine nucleus via addition to simple and accessible reagents such as ninhydrin, o-phenylenediamine, and carbon disulfide. The experimental procedures were straightforward and simple, the products were isolated in 15–86% yields, and. their structure was confirmed by spectroscopic data. The synthesized compounds were evaluated for their antibacterial activity against some Gram-positive and Gram-negative bacteria.
   
     
 
       

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