Aquaculture is the practice of developing aquatic animals and plants under artificial environmental conditions, either in a controlled or semi-controlled environment. Due to high animal protein demand, it is one of the world’s growing food pro- duction industries. It plays a vital role in contributing to food security and lowering the unemployment rate of the world’s growing population. This review article aims to scope sight on the environmental factors that affect the growth and economic production process of Nile tilapia. Many of these factors are listed and analyzed in this review, such as stocking densities; vari- ous feed frequencies and feeding rates; water quality; water temperature; dissolved oxygen concentration; water pH degree; ammonia (NH 3 ), nitrite (NO 2 ), and nitrate (NO 3 ) concentration; feeding regimes; feed cost; and tank culturing system of Nile tilapia. These factors can significantly alter body weight, composition, survival, behavior, feed intake, feed conversion ratio, feeding efficiency, and the health and reproduction of Oreochromis niloticus. Furthermore, feeding, growth, disease risks, and survival rates are all affected by water quality parameters. In general, higher growth performance of O. niloticus in aquaculture can be obtained by keeping the optimum quantity of feed with proper feeding rate and frequency, maintaining a good proportion of stocking density, and regularly evaluating water quality. This review article highlights—in details—the impact of various environmental factors on growth performance criteria of Nile tilapia (Oreochromis niloticus).