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Policosanol ameliorates renal inflammation and pyroptosis in hypercholesterolemic rabbits via modulation of HMGB1/PI3K/mTOR/NLRP3/Caspase-1 pathway
Faculty
Pharmacy
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Mohamed Mahmoud Swedy
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Functional Foods Elsevier Ltd.
Volume:
Keywords :
Policosanol ameliorates renal inflammation , pyroptosis , hypercholesterolemic
Abstract:
Hyperlipidemia represents a major risk factor for cardiovascular and renal diseases. This study aimed to demonstrate the possible ameliorating effects of policosanol (PC) on renal inflammation and pyroptosis. Eighteen male New Zealand rabbits were randomly divided into 3 groups (n = 6/group), one received normal chow diet for 12 weeks while the others received either 0.5 % w/w high cholesterol diet (HCD) or HCD and concurrently treated with PC (5 mg/kg body weight/day) for 12 weeks. Rabbits fed with HCD showed significant increases in body and kidney weights; renal dysfunction, dyslipidemia, oxidative stress status, elevated levels of oxidized low density lipoprotein (Ox-LDL) and renal High-mobility group box 1 (HMGB1). These increases were accompanied with up-regulation of phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling in renal tissue and activation of NOD-like receptor, pyrin domain-containing-3 (NLRP3) inflammasome. Administration of PC concurrently with HCD significantly modulated the HCD-induced activation of Ox-LDL/HMGB1/PI3K/mTOR/NLRP3/Caspase-1 signaling pathway and subsequently attenuated the resulted renal injury.
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Mohamed Mahmoud Swedy, "Pattern of fatty acids as modulator for dietary iron overload and its influences on testicular function of experime", Academic Journals, 2013
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Department Related Publications
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