The Internet of Things is widely used, which results in the collection of enormous amounts of data with numerous redundant, irrelevant, and noisy features. In addition, many of these features need to be managed. Consequently, developing an effective feature selection (FS) strategy becomes a difficult goal. Many FS techniques, based on bioinspired metaheuristic methods, have been developed to tackle this problem. However, these methods still suffer from limitations; so, in this paper, we developed an alternative FS technique, based on integrating operators of the chameleon swarm algorithm (Cham) with the quantum-based optimization (QBO) technique. With the use of eighteen datasets from various real-world applications, we proposed that QCham is investigated and compared to well-known FS methods. The comparisons demonstrate the benefits of including a QBO operator in the Cham because the proposed QCham can efficiently and accurately detect the most crucial features. Whereas the QCham achieves nearly 92.6%, with CPU time(s) nearly 1.7 overall the tested datasets. This indicates the advantages of QCham among comparative algorithms and high efficiency of integrating the QBO with the operators of Cham algorithm that used to enhance the process of balancing between exploration and exploitation.