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CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin‑10 receptor
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
12
Authors:
Gamal Abdelmoniem Mohamed Abedallah
Staff Zu Site
Abstract In Staff Site
Journal:
Scientific reports Nature Publishing Group
Volume:
12
Keywords :
CCR2 promotes monocyte recruitment , intestinal inflammation
Abstract:
Macrophages are a heterogeneous population of mononuclear phagocytes abundantly distributed throughout the intestinal compartments that adapt to microenvironmental specific cues. In adult mice, the majority of intestinal macrophages exhibit a mature phenotype and are derived from blood monocytes. In the steady-state, replenishment of these cells is reduced in the absence of the chemokine receptor CCR2. Within the intestine of mice with colitis, there is a marked increase in the accumulation of immature macrophages that demonstrate an inflammatory phenotype. Here, we asked whether CCR2 is necessary for the development of colitis in mice lacking the receptor for IL10. We compared the development of intestinal inflammation in mice lacking IL10RA or both IL10RA and CCR2. The absence of CCR2 interfered with the accumulation of immature macrophages in IL10R-deficient mice, including a novel population of rounded submucosal Iba1+ cells, and reduced the severity of colitis in these mice. In contrast, the absence of CCR2 did not reduce the augmented inflammatory gene expression observed in mature intestinal macrophages isolated from mice lacking IL10RA. These data suggest that both newly recruited CCR2-dependent immature macrophages and CCR2-independent residual mature macrophages contribute to the development of intestinal inflammation observed in IL10R-deficient mice.
Author Related Publications
Gamal Abdelmoniem Mohamed Abedallah, "Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt", BMC, 2019
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa seed extract: 1. Enhancement of sheep macrophage inflammatory functions in vitro", Alsevier Ltd, 2013
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa oil extract: A natural novel specific conjugal transfer inhibitor of vancomycin resistance from vanA/B-resistant Enterococcus faecium to Staphylococcus aureus", Wiley, 2022
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Gamal Abdelmoniem Mohamed Abedallah, "1- A trial to develop Monocyte-Derived Macrophages tissue culture system ", لايوجد, 1900
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Gamal Abdelmoniem Mohamed Abedallah, "4- Bovine Viral Diarrhea Virus Down Regulate Monocyte-Derived Macrophages inflammatory Functions ", لايوجد, 1900
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Department Related Publications
Ahlaam Abd Al Aziz Gharieb Ibrahim, "Association of Plasmid-Mediated Quinolone Resistance with AmpC- Beta-Lactamase Producing E. coli strains from Different Sources", Zagazig Univerisity, 2014
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Iman Ibrahim Attia Sweilem, "The presence of toxin genes of Clostridium perfringens isolated from camels and humans in Egypt. تواجد جينات السموم في المطثية الحاطمة المعزولة من الإبل والآدميين بمصر", كلية الطب البيطرى كرواتيا, 2010
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Iman Ibrahim Attia Sweilem, "Isolation of Staphylococcus aureus from milk and human with reference to its survival on surfaces. عزل المكور العنقودى الذهبى من الحليب والآدميين مع الإشارة لبقائها على الأسطح.", كلية الطب البيطرى - جامعة الزقازيق, 2013
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Lamia Mohammad Reza Mohammad Noman, "Studies on Antibiotic Resistance of Escherichia coli isolated from poultry and children", Sues Canal Vet. Med. J, accepted for publication (2013), 2013
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Lamia Mohammad Reza Mohammad Noman, "Bacteriological studies of Salmonella typhimurium isolated from cow calves and lambs", Assiut Vet. Med. J. Vol. 60 No. 140 January 2014, 2014
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