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Modulatory Impacts of Multi-Strain Probiotics on Rabbits’ Growth, Nutrient Transporters, Tight Junctions and Immune System to Fight against Listeria monocytogenes Infection
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Naglaa Fathy Said Awad
Staff Zu Site
Abstract In Staff Site
Journal:
Animals MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Volume:
Keywords :
Modulatory Impacts , Multi-Strain Probiotics , Rabbits’ Growth,
Abstract:
Multi-strain probiotics (MSP) are considered innovative antibiotics’ substitutes supporting superior gut health and immunity of farmed rabbits. The promising roles of MSP on performance, intestinal immunity, integrity and transporters, and resistance against Listeria monocytogenes (L. monocytogenes) were evaluated. In the feeding trial, 220 rabbits were fed a control diet or diet supplemented with three MSP graded levels. At 60 days of age, rabbits were experimentally infected with L. monocytogenes and the positive control, enrofloxacin, prophylactic MSP (MSPP), and prophylactic and therapeutic MSP (MSPTT) groups were included. During the growing period, MSP at the level of 1 × 108 CFU/kg diet (MSPIII) promoted the rabbits’ growth, upregulated the nutrient transporters and tight-junction-related genes, and modified cytokines expression. Supplementing MSPTT for L. monocytogenes experimentally-infected rabbits restored the impaired growth and intestinal barriers, reduced clinical signs of severity and mortalities, and attenuated the excessive inflammatory reactions. Notably, enrofloxacin decreased L. monocytogenes and beneficial microbial loads; unlike MSPTT, which decreased pathogenic bacterial loads and sustained the beneficial ones. Histopathological changes were greatly reduced in MSPTT, confirming its promising role in restricting L. monocytogenes translocation to different organs. Therefore, our results suggest the use of MSPTT as an alternative to antibiotics, thereby conferring protection for rabbits against L. monocytogenes infection.
Author Related Publications
Naglaa Fathy Said Awad, "In vitro evaluation of various antimicrobials against field mycoplasma gallisepticum and mycoplasma synoviae isolates in Egypt", Oxford University Press, 2019
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Naglaa Fathy Said Awad, "Phylogenetic Analysis of Infectious Bronchitis Viruses Currently Circulating in the Egyptian Field", Faculty of Veterinary Medicine, Zagazig University, 2019
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Naglaa Fathy Said Awad, "Genetic characterization of rabbit hemorrhagic disease virus from naturallyinfected rabbits in Sharkia governorate, Egypt", Egyptian Society of Virology, 2018
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Naglaa Fathy Said Awad, "Coexistence of Virulence and Antibiotic Resistance Genes in Pasteurella multocida Isolated from Diseased Rabbits", Faculty of Veterinary Medicine, Zagazig University, 2019
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Naglaa Fathy Said Awad, "Molecular Diagnosis of Persistently Very Virulent Infectious Bursal Disease Virus at Sharkia Governorate, Egypt", C M B Association, 2019
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Department Related Publications
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Iman Ibrahim Attia Sweilem, "The presence of toxin genes of Clostridium perfringens isolated from camels and humans in Egypt. تواجد جينات السموم في المطثية الحاطمة المعزولة من الإبل والآدميين بمصر", كلية الطب البيطرى كرواتيا, 2010
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Iman Ibrahim Attia Sweilem, "Isolation of Staphylococcus aureus from milk and human with reference to its survival on surfaces. عزل المكور العنقودى الذهبى من الحليب والآدميين مع الإشارة لبقائها على الأسطح.", كلية الطب البيطرى - جامعة الزقازيق, 2013
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