The introduction of uniportal video-assisted thoracoscopic surgery into the field of minimally invasive thoracic surgery has its revolutionary effect by bringing the surgical trauma to the minimum. As a result, less postoperative pain and complications may be achieved through this technology. This may convince us as thoracic surgeons to become more liberal and to extend the indications of performing 'single-staged' bilateral video-assisted thoracoscopic surgery. Herein, we described our technique in bilateral pulmonary resections. A 32-year-old woman was admitted to our department with 3 small bilateral lesions. Two wedge resections were performed on the left side, followed by S6 segmentectomy on the right side.