Journal: |
Journal of Molecular Liquids
Elsevier
|
Volume: |
|
Abstract: |
Novel mono- and homo bi-nuclear chelates of sulfamerazine-resorcinol azo-dye ligand (H3L) for pharmaceutical
applications were acquired by coupling of sulfamerazine diazonium salt with resorcinol. The
structural formula of H3L and its formed chelates with Cu(II), Ni(II), Zn(II), Cd(II), Hg(II), ZrO(II) and Ce
(III) were investigated using elemental analysis and thermogravimetric analysis, Fourier-transform infrared
spectroscopy (FT-IR), nuclear magnetic resonance (1H NMR), UV–Vis, ESR, transmittance electron
microscope (TEM), X-ray powder diffraction (XRD), magnetic moment and molar conductance. The
obtained results indicated that H3L was chelated with Cu(II) ions in a monobasic di-dentate linked to
the metal ion via azo nitrogen, and dehydrogenated phenolic oxygen in the ortho-position. The remaining
complexes, in addition to the previous coordination centers, H3L chelated with the metal ions through
one N-atom of pyrimidine ring, and deprotonated sulfonamide oxygen in dibasic bimetallic mode.
Based on the spectral and analytical results the formed complexes attained various geometry depending
on the typed of chelated element. Where Ni(II), Zn(II), Cd(II) and Hg(II) complexes attained tetrahedral
geometry, ZrO(II) got square pyramidal geometry, Cu(II) complex accomplished square planar arrangement
and Ce(III) complex had octahedral configuration. Applying Coats-Redfern equations, the activation
thermo-kinetic parameters (E*, DH*, DS*, and DG*) for different degradation stages the inspected chelates
were computed from TGA graphs. Overwhelmingly, the antimicrobial and antitumor efficiency were
investigated for the prepared complexes, which showed high activity after complex formation. The anticancer
activity against human liver carcinoma cells (HepG-2) showed promising results, Ni(II) complex
exhibited the highest anticancer activity (IC50 = 4.68 mg/mL). Molecular docking simulations were also
achieved to evaluate inhibitory efficacy theoretically on the oncogenic protein H-ras (PDB ID: 121P)
and protein of liver cancer 2 (PDB ID: 2JW2).
|
|
|