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Nigella sativa extract potentially inhibited methicillin resistant Staphylococcus aureus induced infection in rabbits: potential immunomodulatory and growth promoting properties
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Gamal Abdelmoniem Mohamed Abedallah
Staff Zu Site
Abstract In Staff Site
Journal:
Animals MDPI
Volume:
Keywords :
Nigella sativa extract potentially inhibited methicillin
Abstract:
Weaning is the most crucial period associated with increased stress and susceptibility to diseases in rabbits. Methicillin-resistant Staphylococcus aureus (MRSA), a historic emergent pathogen related to post weaning stressors, adversely affects rabbit’s growth rate and productive cycle. Since MRSA is rapidly evolving antibiotics resistance, natural products are desperately required to tackle the public health threats posed by antimicrobial resistance. Thus, this study aimed to screen the in vitro antibacterial activity of Nigella sativa extract (NSE) and its interactions with antibiotics against MRSA isolates. Moreover, 200 weaned rabbits were divided into 4 groups to investigate the in vivo superiority of NSE graded levels towards growth performance, tight junction integrity, immune responsiveness and resistance against MRSA. Herein, NSE showed promising antimicrobial activities against MRSA isolates from animal (77.8%) and human (64.3%) origins. Additionally, MRSA isolates exposed to NSE became sensitive to all antimicrobials to which they were previously resistant. Our results described that the growth-promoting functions of NSE, especially at higher levels, were supported by elevated activities of digestive linked enzymes. Post-NSE feeding, rabbits’ sera mediated bactericidal activities against MRSA. Notably, upregulated expression of occludin, CLDN-1, MUC-2 and JAM-2 genes was noted post NSE supplementation with maximum transcriptional levels in 500 mg/kg NSE fed group. Our data described that NSE constitutively motivated rabbits’ immune responses and protected them against MRSA-induced experimental infection. Our results suggest the antimicrobial, growth stimulating and immunomodulation activities of NSE to maximize the capability of rabbits for disease response.
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Gamal Abdelmoniem Mohamed Abedallah, "Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt", BMC, 2019
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa seed extract: 1. Enhancement of sheep macrophage inflammatory functions in vitro", Alsevier Ltd, 2013
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Gamal Abdelmoniem Mohamed Abedallah, "Nigella sativa oil extract: A natural novel specific conjugal transfer inhibitor of vancomycin resistance from vanA/B-resistant Enterococcus faecium to Staphylococcus aureus", Wiley, 2022
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Gamal Abdelmoniem Mohamed Abedallah, "1- A trial to develop Monocyte-Derived Macrophages tissue culture system ", لايوجد, 1900
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Gamal Abdelmoniem Mohamed Abedallah, "4- Bovine Viral Diarrhea Virus Down Regulate Monocyte-Derived Macrophages inflammatory Functions ", لايوجد, 1900
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Department Related Publications
Ahmed Mohamed Abdelaal Mansur, "Abd Elaal, A.M, El-Maghawry,S. Abd El-Razik, W and Eassa, A., (2009): Ultarsonography as diagnostic and prognostic aid for traumatic reticuloperitonitis in cows", لايوجد, 1900
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Alabaas Mohamed Abaas Elnajar , "التغيرات في بعض مكونات الدم في الجاموس الناتجة عن الاصابة بمرض الحمي القلاعية ".", لايوجد, 1900
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Hatem Mohamed Sleim Mouhamd, " "ملاحظه تكوين حصوات المجارى البولية في عجول التسمين المخصية مع إشارة خاصة للتدابير الوقائية" ", لايوجد, 1900
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Hamed Attia Mohamed Sayed, "تأثير العلائق الصيفية والشتوية على نمو وزن الجسم وبعض مركبات الدم فى الجاموس عند أعمار مختلفة ", لايوجد, 1900
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