Design, Synthesis, Docking, 2D-QSAR Modelling, Anticancer and Antioxidant Evaluation of Some New Azo-Compounds Derivatives and Investigation of Their Fluorescence Properties

Faculty Science Year: 2022
Type of Publication: ZU Hosted Pages: 14
Authors:
Iman Omar Hamid Omar
Journal: ChemistrySelect Wiley Volume: Volume 7
Keywords : Design, Synthesis, Docking, 2D-QSAR Modelling, Anticancer    
Abstract:
In this article, A number of diazine and triazine molecules were synthesized by using innovative methods. All the obtained compounds were elucidated by means of IR, 1H- NMR, 13C- NMR, and mass spectra. The effect of the compounds on human cancer (HEPG-2) and (MCF-7) was revealed as well as studying their antioxidant, antimicrobial activity. However, the main biological activity on this protocol was as an anticancer on human cancer (HEPG-2) and (MCF-7), and this activity was supported by computational studies (molecular docking and 2D-QSAR modelling (2015)). The molecular docking provides more information regarding the ways that the chemicals created can attach to the DNA-binding domain of Topoisomerase I (PDB ID: 1RR8). The predicted IC50 of the prepared compounds was related to the predicted IC50 by using QSAR through MOE software.
    
     
 
       

Author Related Publications

  • Iman Omar Hamid Omar, "Design, Synthesis, Molecular Docking, and Evaluation Antioxidant and Antimicrobial Activities for Novel 3-Phenylimidazolidin-4-One and 2-Aminothiazol-4-One Derivatives", MDPI, 2022 More
  • Iman Omar Hamid Omar, "Cyclization of N-benzyl cyanoacetamide: Novel synthesis and biological activity of pyrrole, pyrimidine, and pyran derivatives", Wiley-blackwell, 2020 More
  • Iman Omar Hamid Omar, "Synthesis and fluorescent properties of some Furan-tagged Thieno[2,3-d]pyrimidines and Thieno[2,3-d:4,5-d'] dipyrimidines", Wiley-blackwell, 2020 More
  • Iman Omar Hamid Omar, "Heterocyclization of Aromatic Amino Acids: Novel Syntheses and Antibacterial Activity of Fused, Non-fused, and Spiro Polyheterocyclic Derivatives", United States Pleiades Publishing, 2020 More
  • Iman Omar Hamid Omar, "Heterocyclization of Cyanoacetamide Derivatives: Synthesis and Biological Activity of Novel Azoles and Azines", United States Pleiades Publishing, 2021 More

Department Related Publications

  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Electronic Properties of Organic Complexes. 2. Reactive Azodyes", Spain, 1993 More
  • Mohamed Gamal Helmy Mohamed Abdelwahed, "Electrical Behaviour of some Azodye Mixed Ligand with Gd3+ and Er3+. b", Peru, 1994 More
  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Mohammed Aref Awad Allah Abu Zyd, "Synergistic positive effects of nano barium silicate on the hydration rate and phase composition of alkali-activated slag", Elsevier, 2022 More
  • Ahmed Abdelmoniem Ahmed Amer, "Synthesis and characterization of some calcium aluminate phases from nano-size starting materials", 0366-3175/© 2020 SECV. Published by Elsevier Espana, ˜ S.L.U, 2020 More
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