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H5N1 Avian Flu Infection in Hubbard Broiler Chicken Can Be Prevented or Cured by Methylated Soy Protein During 42 Days Rearing
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Hala Mohamed Nabil Tolba
Staff Zu Site
Abstract In Staff Site
Journal:
PROBIOTICS AND ANTIMICROBIAL PROTEINS SPRINGER
Volume:
Keywords :
H5N1 Avian , Infection , Hubbard Broiler Chicken
Abstract:
Methylated soy protein (MSP) which is positively charged with enhanced hydrophobicity may have antiviral action. This study is verifying if MSP can act inhibit H5N1 inside an animal model. Five groups of Hubbard chicks were challenged at the 25th day of the experiment with AIV virus (H5N1; 0.1 × 105 EID50/mL); 1 group did not receive any treatment (positive control), 2 groups (protective) received treatments before and after the challenge (0.1–0.2 g/L in drinking water ad libitum), and 2 groups (curative) received them only after the challenge. The positive control recorded 100% mortality after 3–5 days of infection. Chicken receiving MSP (0.2 g/L), delayed reaching to 100% mortality to the 7th day after infection, while those receiving MSP low level (0.1 g/L) could achieve 100% survival during the whole incubation period (42 days), either as a preventive or curative approach. H5N1 virus was not detected in the tracheal and cloacal swabs of the groups receiving 0.1 g/L, opposite to the positive control. The low level of MSP (0.1 g/L) reduced the viral titer to about 1% of the positive control in the protective and curative groups after 5 days of infection, and could maintain the bird body-weight, liver and kidney function, and histopathological status within the normal values. Humoral and TLC response in the group receiving both the virus and the MSP (0.1 g/L) may refer to a possibility that MSP-weakened virus has transformed into a vaccine-like material eliciting host immunity.
Author Related Publications
Hala Mohamed Nabil Tolba, "Risk factors associated with Chlamydia psittaci infections in psittacine birds and bird handlers", Wiley, 2018
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Hala Mohamed Nabil Tolba, "Molecular identification of avian influenza virus subtypes H5N1 and H9N2 in birds from farms and live bird markets and in respiratory patients", Peer journal, 2018
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Hala Mohamed Nabil Tolba, "Seroprevalence and risk factors associated with Toxoplasma gondii infection in domestic rabbits and humans", ELSEVIER, 2017
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Hala Mohamed Nabil Tolba, "Molecular Diagnosis of Persistently Very Virulent Infectious Bursal Disease Virus at Sharkia Governorate, Egypt", Links Research, 2019
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Hala Mohamed Nabil Tolba, "EFFECT OF THE MEDICINAL PLANT (AZADIRACHTA INDICA) ON Chlamydophila psittaci INFECTION IN BROILER CHICKENS", UNIV LJUBLJANA, VETERINARY FACULTY, GERBICEVA 60, LJUBLJANA, SLOVENIA, 1000, 2018
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Department Related Publications
Ahmed Abdelsamiea Hassan Aali, "عزل وتوصيف فيروس إلتهاب الشعب الهوائية المعدى فى الدواجن", لايوجد, 1900
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Shimaa Mohamed Galal, "Cleavage site stability of Egyptian highly pathogenic avian influenza viruses in backyard chickens during 2009-2011", Journal of Microbiology, Immunology and Infection, 2013
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Fatma Mohamed Abdallah, "Genetic Analysis of Infectious Bronchitis Virus Isolated from Egyptian Broiler Chicken Flocks between 2017 and 2018", Nexus academic, 2019
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Ahmed Abdelsamiea Hassan Aali, "Genetic Analysis of Infectious Bronchitis Virus Isolated from Egyptian Broiler Chicken Flocks between 2017 and 2018", Nexus academic, 2019
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Gamelat Kottb Farag Kotb, "Genetic Analysis of Infectious Bronchitis Virus Isolated from Egyptian Broiler Chicken Flocks between 2017 and 2018", Nexus academic, 2019
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