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Zinc Oxide Nanoparticles (ZnO-NPs) Suppress Fertility by Activating Autophagy, Apoptosis, and Oxidative Stress in the Developing Oocytes of Female Zebrafish
Faculty
Science
Year:
2022
Type of Publication:
ZU Hosted
Pages:
21
Authors:
Susan Attia Moawad
Staff Zu Site
Abstract In Staff Site
Journal:
Antioxidants MDPI
Volume:
(8)11
Keywords :
Zinc Oxide Nanoparticles (ZnO-NPs) Suppress Fertility
Abstract:
In vertebrates, the core mechanisms that control gametogenesis are largely multiple, complex, successive, and orchestrated by intrinsic and extrinsic factors. However, age, health status, and hormonal activity are important factors for good fertility; other intangible intracellular molecular mechanisms that manage oocyte development are still unclear. The present study was designed to elucidate the ultrastructure changes in the ovary in response to its exposure to zinc oxide nanoparticles (ZnO-NPs) and to explore the role of autophagy and apoptosis during egg maturation and ovulation on the fertility of female zebrafish. In our study, ZnO-NPs could induce cytotoxicity in the maturing oocyte by activating autophagy and apoptosis in a caspase-dependent manner and could induce oxidative stress by generating reactive oxygen species (ROS) that elevated the mutated ovarian tP53 protein. Simultaneously, necroptosis developed, mimicking the features of apoptosis and necrosis. Collectively, ZnO-NPs created a suitable necrotic environment that led to follicular developmental retardation that altered oocyte ovulation and reduced fecundity of female zebrafish.
Author Related Publications
Susan Attia Moawad, "A Comparative Morphological and Histological Study of the Olfactory Organ in Two Models of Bony Fishes (Mugil cephalus and Malapterurus electricus): A light and Electron microscopic study.", مجلة كلية العلوم, 2013
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Susan Attia Moawad, "strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish", china, 2020
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Susan Attia Moawad, "Dietary Supplementation of Nile Tilapia (Oreochromis niloticus) With Panax ginseng Essential Oil: Positive Impact on Animal Health and Productive Performance, and Mitigating Effects on Atrazine- Induced Toxicity", Frontiers, 2022
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Susan Attia Moawad, "Benefits of Chlorella vulgaris against Cadmium Chloride-Induced Hepatic and Renal Toxicities via Restoring the Cellular Redox Homeostasis and Modulating Nrf2 and NF-KB Pathways in Male Rats", MDPI, 2023
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Susan Attia Moawad, "In ovo protective effects of chicoric and rosmarinic acids against Thiacloprid-induced cytotoxicity, oxidative stress, and growth retardation on newly hatched chicks", Elsevier, 2023
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Department Related Publications
Samir Abdullah Taha, "Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaea natalensis snails", كلية العلوم, 2013
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Wageha Abdullah Ibrahim Mustafa, "Pathogenicity of entomopathogenic fungi on larvae of Culex pipiens mpsquitoes (Diptera : Culicidae)", (American-Eurasian Network for Scientific Information (AESNI, 2013
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Susan Attia Moawad, "A Comparative Morphological and Histological Study of the Olfactory Organ in Two Models of Bony Fishes (Mugil cephalus and Malapterurus electricus): A light and Electron microscopic study.", مجلة كلية العلوم, 2013
More
Iman Hassan Mohammed Sheikh, "Light and scanning electron microscopic study of the dorsal lingual papillae of the rat Arvicanthis niloticus (Muridae, Rodentia)", Elsevier, 2012
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Iman Hassan Mohammed Sheikh, "Scanning Electron Microscopic Studies of Gill Arches and Rakers in Relation to Feeding Habits of Some Fresh Water Fishes", Elsevier, 2013
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