Copyright protection of medical images is a vital goal in the era of smart healthcare systems. In recent telemedicine applications, medical images are sensed using medical imaging devices and transmitted to remote places for screening by physicians and specialists. During their transmission, the medical images could be tampered with by intruders. Traditional watermarking methods embed the information in the host images to protect the copyright of medical images. The embedding destroys the original image and cannot be applied efficiently to images used in medicine that require high integrity. Robust zero-watermarking methods are preferable over other watermarking algorithms in medical image security due to their outstanding performance. Most existing methods are presented based on moments and moment invariants, which have become a prominent method for zero-watermarking due to their favorable image description capabilities and geometric invariance. Although moment-based zero-watermarking can be an effective approach to image copyright protection, several present approaches cannot effectively resist geometric attacks, and others have a low resistance to large-scale attacks. Besides these issues, most of these algorithms rely on traditional moment computation, which suffers from numerical error accumulation, leading to numerical instabilities, and time consumption and affecting the performance of these moment-based zero-watermarking techniques. In this paper, we derived multi-channel Gaussian–Hermite moments of fractional-order (MFrGHMs) to solve the problems. Then we used a kernel-based method for the highly accurate computation of MFrGHMs to solve the computation issue. Then, we constructed image features that are accurate and robust. Finally, we presented a new zero-watermarking scheme for color medical images using accurate MFrGHMs and 1D Chebyshev chaotic features to achieve lossless copyright protection of the color medical images. We performed experiments where their outcomes ensure the robustness of the proposed zero-watermarking algorithms against various attacks. The proposed zero-watermarking algorithm achieves a good balance between robustness and imperceptibility. Compared with similar existing algorithms, the proposed algorithm has superior robustness, security, and time computation.