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Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Amany Abdalaziz
Staff Zu Site
Abstract In Staff Site
Journal:
Evidence-based Complementary and Alternative Medicine Hindawy
Volume:
Keywords :
Neuropharmacological , Antidiabetic Potential , Lannea coromandelica (Houtt.)
Abstract:
Abstract The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.
Author Related Publications
Amany Abdalaziz , "Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed", Elseviere, 2022
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Amany Abdalaziz , "Alleviative effects of dietary Indian lotus leaves on heavy metals-induced hepato-renal toxicity, oxidative stress, and histopathological alterations in Nile tilapia, Oreochromis niloticus (L.)", Elsevier B.V., 2019
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Amany Abdalaziz , "Estimation of organochlorine pesticides and heavy metal residues in two species of mostly consumed fish in Sharkia Governorate, Egypt", Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP, 2016
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Amany Abdalaziz , "Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat pups brain", elsevier, 2015
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Amany Abdalaziz , "Identification of Species Adulteration in Raw Milk and Butter Using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism", IDOSI Publications, 2015
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Department Related Publications
Salah Meselhy Hamza , "Preliminary and confirmatory screening tests for identification the active principles of Nerium Oleander Cardinoloides extract on albino rats ", لايوجد, 1900
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Magdy Fekry Aboelfotoh, "التسمم باميتالاكسيل في الفئران البلدي المجرعة عن طريق الفم", لايوجد, 1900
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Magdy Fekry Aboelfotoh, "down regulation of male specific cytochrome p 450 by profenofos", لايوجد, 1900
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Mervat Hassan Hassanien Ghonem , "Some toxicological effects of herbicide linuron (Afalon) in rats ", لايوجد, 1900
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Mervat Hassan Hassanien Ghonem , "Residual analysis of different organs of dams and its foeti administered of nerium oleander cardenolides extract ", لايوجد, 1900
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