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Sustained Functioning Impairments and Oxidative Stress with Neurobehavioral Dysfunction Associated with Oral Nicotine Exposure in the Brain of a Murine Model of Ehrlich Ascites Carcinoma: Modifying the Antioxidant Role of Chlorella vulgaris
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Taghreed Saber Mohamed Sayed Ahmd
Staff Zu Site
Abstract In Staff Site
Journal:
Biology MDPI
Volume:
Keywords :
Sustained Functioning Impairments , Oxidative Stress with Neurobehavioral
Abstract:
Abstract: Background: This study provides a model for studying the mechanism(s) responsible for the nervous tissue damage and misfunctioning that occurred due to oral nicotine exposure, considered a stress factor, during the presence of Ehrlich ascites carcinoma bearing in the mouse model (EAC). The mitigating role of Chlorella vulgaris (CV) against nicotine-induced brain damage was evaluated. Methods: Eighty Swiss female mice were classified into four groups, these were the control, the CV group, the nicotine group(100 μg/kg), and the combination group. Oxidant/antioxidant status, proinflammatory cytokines levels, DNA damage, quantitative microscopical lesions, and Caspase 3, Bcl-2 proteins were assessed in the current study. Levels of dopamine (DA) and gammaaminobutyric acid (GABA) were also evaluated. Results: Nicotine was found to cause pronounced neurobehavioral alterations, increase the mortalities oxidative stress DNA damage, and augment the inflammatory response in brain tissue alongside the microstructural alteration. The administration of CV with nicotine in EAC-bearing mice rescued the detrimental effects of nicotine. Conclusions: CV aids in reducing the harmful effects of nicotine and returns the conditions caused by
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Taghreed Saber Mohamed Sayed Ahmd, "Ginger protects rats against cadmium-induced hepatotoxicity", Cambridge Scientific Abstracts, 2013
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Taghreed Saber Mohamed Sayed Ahmd, "Expression of cell death genes estimates time since death in rats", Romanian Society of Legal Medicine, 2016
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Department Related Publications
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