Groundwater exploration is the most promising way to overcome water scarcity in hyperarid regions around the world. Due to the scarcity of hydrogeological information in these regions, groundwater exploration is a challenging issue requiring the joint application of satellite and land-based information to delineate the groundwater aquifers in such harsh environments. In this research, an integrative approach was undertaken for groundwater exploration in the southwestern corner of Egypt as one of the most hyper-arid regions in North Africa. To fll the knowledge gap in this large area, two high-resolution satellite gravity datasets (EIGEN-6C4 and TOPEX-1min) were employed in combination with land-based geophysical surveys for a better understanding of groundwater potentialities in terms of structural controls. Further, the approaches of high-pass flter, tilt angle derivative, and enhanced horizontal gradient amplitude were used to analyze EIGEN-6C4 dataset. Additionally, 2D and 3D models along with a high-pass fltered gravity map were constructed to provide the subsurface barriers and preferential groundwater fow pathways. Several NNE windows have been recognized, particularly to the east of Gabel Kamel along Uweinat-Aswan uplifting allowing groundwater fow along northeastern structural trends. To verify this assumption, land-based magnetic and DC resistivity sounding surveys were executed at two selected sites based on the interpretation of satellite gravity and remote sensing data. The resistivity and 2D magnetic modeling reveal the presence of remarkable sub-basins with sufcient saturated sedimentary cover. Ultimately, the review of the diferent datasets, including satellite gravity and land-based geophysical investigations, facilitated the geological interpretation for detecting the structural controls on the groundwater fow paths and produced satisfactory results at shorter time frames and lower costs compared to typical groundwater exploration in arid or hyper-arid regions of the same characteristics elsewhere.