This study aims to examine the impacts of the variable nanofluid properties on the compressible flow over an inclined irregular surface. The density, dynamic viscosity and thermal conductivity of the nano liquid are assumed to be dependent on the temperature, and the viscous dissipation in this case is introduced. Sinusoidal formulations for the unsmoothed surface together with the governing system in case of GrL !1 are presented. The temperature on the edge is, also, variable and depending on the discerption function of the surface. The nonlinear radiation is taken into account, and the two-phase model for the nanofluid is applied. A fully implicit finite difference method (FDM) is used to solve the governing system. The major outcomes revealed that the skin friction coefficient and Nusselt number are rising as the compressibility parameter d is altered. Also, the maximization of the thermal conductivity-variation b1 is better for the velocity and temperature behaviors.