Little knowledge is available about the effects of fluoride exposure on the tongue. This study evaluates the effects of sodium fluoride (NaF) on the tongue ultrastructure and detects the ameliorative effects of resveratrol. 40 adult albino rats were separated into 4 groups: the control group was given a balanced diet and purified water. The NaF treated group: received 10 mg/kg/day dissolved in 2.5 ml distilled water once daily for 30 days orally. The NaF+ resveratrol group: received NaF 10mg/kg/day orally together with resveratrol in a dose of 30 mg/kg daily for 30 days. The resveratrol group was subjected to resveratrol in a dose of 30 mg/kg/ day by oral gavage for 30 days. Sections were stained with hematoxylin & eosin, and Masson's trichrome. TNF-α immunohistochemical study and electron microscopic examinations were done. The oxidative stress markers malondialdehyde, antioxidant reduced glutathione, and the total antioxidant capacity were measured. The NaF group revealed ulceration, necrotic muscle fibers, distorted papillae & a significant increase in MDA level, and a significant decrease in GSH & the total antioxidant levels. In the NaF + resveratrol group, pathological changes were less, and the oxidant levels were decreased by the administration of resveratrol with NaF. In conclusion: NaF adversely affects the ultrastructure of the adult rat tongue and resveratrol can ameliorate this effect.