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Therapeutic effect of the mesenchymal stem cells on vigabatrin-induced retinopathy in adult male albino rat
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
217-228
Authors:
Ayat Mahmoud Ibrahim Salem
Staff Zu Site
Abstract In Staff Site
Journal:
Anatomy and Cell Biology Korean Association of Anatomists
Volume:
2093-3673 pISSN:2093
Keywords :
Therapeutic effect , , mesenchymal stem cells , vigabatrin-induced
Abstract:
Vigabatrin (VGB) is an effective antiepileptic drug used mainly to treat infantile spasms and refractory complex partial seizures. However, using VGB was restricted as it was known to cause retinal toxicity that appears as a severe peripheral visual field defect. Accordingly, this study was conducted to examine the histopathological and biochemical effects of VGB on the retina in adult male albino rats and assess the possible therapeutic role of mesenchymal stem cells (MSCs) against this potential toxicity. The rats were divided into three groups (control group, VGB group, and VGB/MSCs group), one week after 65 days of VGB treatment ± MSCs. The right eyeballs were prepared for histological and immunohistochemical examination, whereas the left eyeballs were prepared for real-time polymerase chain reaction analysis. Our results demonstrated that MSCs ameliorated retinal pathological changes and downregulated the expression of glial fibrillary acidic protein, vascular endothelial growth factor, and synaptophysin after VGB administration suggesting MSCs function and vascular modulating effect. Moreover, MSCs regulate retinal tissue gene expression of BAX, Bcl-2, BDNF, NGF, synapsin, interleukin (IL)-6, IL-1β, and occludin suggesting MSCs antiapoptotic and immunomodulating effect. In conclusion, MSCs administration could be a suitable therapeutic line to ameliorate VGB-induced retinopathy.
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Ayat Mahmoud Ibrahim Salem, "Mesenchymal stem cells and differentiated insulin producing cells are new horizons for pancreatic regeneration in type I diabetes mellitus", International Journal of Biochemistry and Cell Biology, 2017
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Ayat Mahmoud Ibrahim Salem, "Comparative study of oral versus parenteral crocin in mitigating acrolein‑induced lung injury in albino rats", Nature Portfolio, 2022
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Ayat Mahmoud Ibrahim Salem, "Ameliorative effect of capsaicin against cardiac dysfunction induced by high fat diet in adult male rat", Sociedad Anatomica Espanola., 2021
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Ayat Mahmoud Ibrahim Salem, "Diagnosis of Interstitial Lung Disease in Connective Tissue Disease Children: Retrospective Radiological Study", Zagazig University, Faculty of Medicine, 2022
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Ayat Mahmoud Ibrahim Salem, "Molecular evidence of the amelioration of toluene induced encephalopathy by human breast milk mesenchymal stem cells", springer nature, 2022
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Department Related Publications
Ashraf Saber Bayoumi Hegab, "التاثير المحسن لفيتامين هـ ضد سمنه على التركيب النسيجى للخصيه والنمط الصبغى في الجرذان البيضاء البالغه ", لايوجد, 1900
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Gamal Mohamed Zain Elabdein, "تكوين الصمام السمعى الظاهر والغشاء الطبلى في الفئران قبل الولادة", لايوجد, 1900
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Gamal Mohamed Zain Elabdein, "التركيب الدقيق للخلايا المهديه والافرازية لقمع البويضات في الارانب ", لايوجد, 1900
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