Background:The COVID-19 pandemic was ongoing global stress encountered by individuals with pre-existing chronic illnesses. This study aimed to evaluate the perceived fears of contracting COVID-19 virus infection (FCV), and to address the associated correlates among patients with multiple sclerosis (MS) during the pandemic. Subjects and methods:A cross-sectional study included a total of 120 Egyptian patients with MS who were following up at the Zagazig University neurology outpatient clinics during the COVID-19 outbreak between May 1st and October 31st, 2020. The participants, consecutively selected by the convenience sampling method, were interviewed using the fear of COVID-19 scale (FCV-19S), Hospital Anxiety and Depression Scale (HADS), Expanded Disability Status Scale (EDSS), and Five-item Modified Fatigue Impact Scale (MFIS-5) for assessment of FCV, comorbid anxiety and depressive symptoms, associated fatiguability, and levels of disability, respectively. Results:Around 58% of patients with MS (n=69) experienced intensified FCV. Those who were unmarried, reporting higher levels of anxiety and depression, diagnosed with primary or secondary progressive MS subtypes, with a longer course of illness, and associated fatigability and disability, were more likely to experience FCV. Comorbid anxiety symptoms were positively correlated with illness duration (r=0.19, P=0.039), increased fatigue (r= 0.47, P<0.001), and disability (r=0.36, P<0.001), while depressive symptoms were positively correlated with increased fatigue (r= 0.37, P<0.001), and disability (r=0.30, P<0.001). Conclusions:FCV was prevalent among patients with MS. Being unmarried, heightened anxiety, longer duration of illness, and associated fatiguability would predict FCV. Both psychological and physical assessment measures of patients with MS should be regularly implemented.