ABSTRACT Background: Miscarriage is spontaneous expulsion of product of conception from the uterus before viability (20 weeks) or if fetus less than 500 gm, or its length less than 25 cm. Bacterial vaginosis is extremely prevalent condition, although it is not a reportable disease. Up to 50% of pregnant women have been found to have BV. Methods; In this study, we assessed 219 pregnant women for the association between bacterial vaginosis and first trimester miscarriage by screening for bacterial vaginosis using Nugent gram stain scoring system among the pregnant women at 7 weeks of gestation and follow them up to the end of first trimester. Using Nugent gram stain scoring system and the result of the culture, we divided pregnant women into to 2 groups: Group I: Women who are negative for BV (167 women, 76.3%). Group II: Positive for bacterial vaginosis (52 women, 23.7%). Then, we followed them up to the end of first trimester. We choose 13 weeks as an end point, as our study was designed to investigate first trimester miscarriage. we compared the two groups regarding the rate of first trimester miscarriage. Results: In the current study, the prevalence of bacterial vaginosis among the pregnant women included was 23.7 %. Among the 219 women included in the study, 38 women (17.4%) miscarried during the first trimester and 181 women (82%) continued their pregnancies after 13 weeks. Conclusion there is no between bacterial vaginosis and first trimester miscarriage when comparing pregnant women with bacterial vaginosis to women who are negative for bacterial vaginosis