Background: Thyroid nodule results in morbidity due to local compression or hyperthyroidism. There are several methods available now, including Radiofrequency Ablation (RF), for image-guided ablation of benign thyroid nodule. Objective: This study's goal is to assess how well RF ablation works for managing benign solitary thyroid nodule. Patients and methods: This study involved 40 participants from the internal medicine and endocrinology department's outpatient clinic at Zagazig University Hospitals. All subjects with benign thyroid nodule received RF ablation, and six-month follow-up were carried out. Results: Thyroid Imaging Reporting and Data Systems (TIRADS) 2, TIRADS 3, and TIRADS 4 categories were present in 20%, 60%, and 20% of cases, respectively. Regarding the initial assessment before RF; the mean values of TSH, T3 and T4 were 3.6 ± 0.87, 2.76 ± 0.39 and 1.07 ± 0.23, respectively. The mean size of nodules was 9.51 ± 2.11. Concerning echogenicity, 53.3% of patients were isoechoic.73.3% of patients had no calcifications; 80% had regular contour. Regarding the final assessment at 6 month after RF; the mean values of TSH, T3 and T4 were 1.86 ± 0.43, 2.8 ± 0.41 and 1.11 ± 0.21, respectively. The mean size of nodules was 2.3 ± 0.43. About 93.3 % of patients had no calcifications. All managed subjects with RF ablation had 100 % regular contour with no halo. Conclusion: RF ablation is regarded as a successful technique for the management of benign thyroid nodules.