Background: The optimal analgesic regimen for major surgery should provide adequate pain relief, allow early mobilization, early return of gut function and feeding, and not cause complications. The cornerstone of analgesia remains multimodal analgesia combining regional analgesia or local anesthetic techniques and trying to avoid parenteral opioids and their side effects. Multiple prospective studies have demonstrated that minimizing opioids is associated with earlier return of bowel function and shorter length of hospital stay Aim of the Study: The aim of the study is the selection of best method for analgesia transversus abdominis plane block or IV PCA to control postoperative pain after cesarean section. Materials & Methods: This study was a randomized control trial which included 84 women having indication for cesarean delivery with pfannenstiel incision under spinal anesthesia who fulfilled the inclusion criteria in Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University in the period from march 2021 to September 2021. Results: we found that both group Ⅰ and Ⅱ had statistically insignificant in VAS, additional analgesic need p>0.05.both group Ⅰ and Ⅱ had statistically insignificant in HR, RR, MAP and SPO2 p>0.05.There was significant difference in between two studied groups as regard nausea-vomiting in 1st hr. P<0.05, but no difference was observed after the 1st hour.There was no statistically significant difference among two studied groups regarding early mobilization and early bowel movement p>0.05, with early mobilization and early bowel movement more in group Ⅰ than group Ⅱ at 3rd hr. Conclusion: The present study demonstrated that transversus abdominis plane block is effective as IVPCA in pain control after cesarean section.