Context: The prognostic significance of expression of V-Crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) and Protein kinase CK2 β in endometroid carcinoma is not fully clarified. Aim: To assess the prognostic values and clinicopathological roles of CRKL and CK2 β expression in endometroid carcinoma by correlation their expression levels with clinicopathological parameters, response to therapy, and recurrence of the tumor and patients survival. Settings: Faculty of Medicine, Zagazig University, and Mansoura University. Methods: CRKL and CK2 β expressions were evaluated in 50 paraffin blocks EC patients that were followed up for 5 years. The relationship between their level of expressions, clinicopathological criteria and prognosis of patients was analyzed. Statistical analysis used: SPSS 22.0 for windows (SPSS Inc., Chicago, IL, USA) and MedCalc windows (Software bvba 13, Ostend, Belgium). Results: High expression of CRKL and CK was positively correlated with higher grade of the tumor (p = 0.004 and 0.006 respectively), presence of L.N metastases (p = 0.009 and 0.003 respectively), presence of distant metastases (p = 0.029 and 0.003 respectively) and advanced FIGO stage (p < 0.001), poor response to therapy (p = 0.046 and 0.005 respectively), higher incidence of recurrence of the tumor after therapy (p = 0.004 and 0.048 respectively), higher incidence of cancer progression p = 0.018 and 0.044 respectively), poor PFS (p = 0.008 and 0.013 respectively), and OS rates (p < How to cite this paper: Kaf, R.M., El-Beshbishi, W., Obaya, A.A., Ahmed, R.Z., Helal, K.F., Ramadan, M.SH., Almoregy, A.S., Heggy, I.A. and Harb, O.A. (2019) CRKL and CK2 β over Expression Are Independent Predictors of Patients Survival in Endometrioid Endometrial Carcinoma. Open Journal of Obstetrics and Gynecology, 9, 479-493. https://doi.org/10.4236/ojog.2019.94047 Received: March 18, 2019 Accepted: April 13, 2019 Published: April 16, 2019 Copyright © 2019 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access R. M. Kaf et al. DOI: 10.4236/ojog.2019.94047 480 Open Journal of Obstetrics and Gynecology 0.001). Conclusion: CRKL and CK2 β overexpression in endometrial carcinoma is associated with worse clinicopathological parameters and poor prognosis.