Background: The most prevalent corneal ectatic condition is keratoconus (KC). It is characterized by a thin, cone shaped cornea that causes myopia, uneven astigmatism, and visual impairment. The Aim of this study: was to evaluate vision-related quality of life in keratoconus patients at Zagazig University Hospitals. Research Design: In this study, a descriptive design was adopted. Setting: The research was carried out in the Zagazig University Hospitals' Ophthalmology Outpatient Clinics. Tool of data collection and subjects: A self-administered questionnaire based on the National Eye Institute Visual Functioning Questionnaire – 25 (VFQ-25) was used to measure the visual functioning of 54 male and female patients. Results: The findings revealed that 42.6 percent of the sample were between the ages of 31 and 40 years, that almost three-fifths of the research sample (59.3%) were male and employees, that 63 percent were married, and that 83.3 percent were nonsmokers. The findings also demonstrated that patients with Keratoconus score had highly statistically significant variations in age, educational level, employment, smoking, and total visual quality of life (P<0.001). Conclusion: The study concluded that Keratoconus has a negative effect on the majority of patients’ vision-related quality of life. Recommendations: It was suggested that all nurses be trained on effective intervention for patients with keratoconus in order to improve their eyesight standard of living. Keywords: Vision-related quality of life, Keratoconus, Patients.