Background: The coronavirus disease 2019 pandemic has touched almost every zone. Personal protective equipment is the last line of preservation of healthcare providers. Due to the prolonged use of PPE, many adverse skin reactions may happen. The aim of the study to: Explore the difficulties and skin damages caused by personal protective equipment among nurses caring for COVID-19 Patients. Design: A descriptive research design was applied in this study. Setting: The study was performed at the Heart and Chest Diseases Hospital in Zagazig University Hospitals. Subjects: This study was implemented on (30) nurses, majority of nurses were females, their ages ranged between 20-50 years and participated in the study. Tools: In this study, a questionnaire to assess the difficulties and self-reported skin damages among the nurses with questions on demographics and a questionnaire concerning personal protective equipment and mainly focused on difficulties and skin damages. Results: The common clinical symptoms of skin damages were scars in the large part of the nose, pain in the back ears, excessive sweating, 58.1% of nurses had difficulty related to prolonged time of using personal protective equipment. Conclusion: PPE among HCWs is imperative to avert the widespread diffusion of COVID-19 but could be detrimental due to utilization for long periods. Recommendation: A comprehensive program should be taken for nurses about the proper PPE use to prevent these difficulties and skin damages. Keywords: Personal Protective Equipment (PPE), Difficulties, Skin Damages Covid-19, Nurses.