This work aimed to study the residue dynamics of two pesticides applied on strawberry plants and to assess their associated risks. Hexythiazox and spinosad were applied separately on mature-stage strawberry plants. Fruit and leaf samples were collected at different times from 2 h to 15 days after application and analyzed using HPLC. The results showed that strawberry leaves contained higher initial amounts of the tested pesticides than fruit. The rates of loss of the initial deposits were higher in strawberry fruit than in leaves. The half-life (t½) values of hexythiazox and spinosad were 2.23 and 3.24 days in strawberry fruit and 2.05 and 2.86 days in leaves, respectively. Regarding MRLs and risks, washed and unwashed fruits of strawberry could be consumed safely at 6 days of hexythiazox or spinosad application and after 2 h when harvested strawberry fruits were processed as jam.