The research aimed to develop a diverse training program in the light of genetic markers (ACE) for juniors in the 1500m race that took place in the National Project for the Gifted in Sharkia Governorate and to know its effect on some physical variables such as endurance of speed and maximum speed, endurance of the muscles of the legs and endurance of the muscles of the arms, and some physiological variables such as pulse during Rest after exertion, blood lactate rate, systolic blood pressure after exertion, dehydrogenase enzyme, beta-endorphin level in the blood, in addition to the digital level of the 1500m race that ran. The research tools were: physical and functional measurements - the proposed varied training program, and the statistical methods used such as arithmetic mean - standard deviation - median - skew coefficient - simple correlation coefficient - "t" test - improvement ratios. Among the most important results: 1- Diversity of training in the light of genetic markers positively affects the improvement of physical variables (maximum speed - speed endurance). The general endurance of the muscles of the legs - the general endurance of the musclesof the arms) among the members of the research sample. 2- Diversity of training in the light of genetic markers positively affects the improvement of physiological variables (resting pulse - pulse after exertion - blood lactate rate – systolic blood pressure after exertion - dehydrogenase enzyme - beta-endorphins) amongthe research sample. 3- The effect of the proposed training program on developing the physical and physiological variables and the numerical level among the research sample members who possessed the ID gene better compared to the members of the sample who had the DD gene. Recommendations: 1- Attention to diversity in training because it has a positive impact on some physical and physiological variables and the digital level of the 1500m runners. 2- Taking into account the genetic markers when classifying and selecting middle and long- distance juniors. 3- Directing training according to the type of the ACE gene and the genetic indicators of theclassifications ID and DD, because they have an effective impact on the development of some physical and physiological variables that affect the digital level of the 1500m race.