Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Olive Leaf Extract Attenuates Chlorpyrifos Induced Neuro and Reproductive Toxicity in Male Albino Rats
Faculty
Agriculture
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Nashwa Ahmed Ali Mohamed Elshaer
Staff Zu Site
Abstract In Staff Site
Journal:
Life MDPI
Volume:
Keywords :
Olive Leaf Extract Attenuates Chlorpyrifos Induced
Abstract:
Chlorpyrifos (CPF) is a common organophosphorus insecticide. It is associated with negative consequences such as neurotoxicity and reproductive injury. This study aimed to observe the ability of olive leaf extract to attenuate chlorpyrifos toxicity, which induced neuro- and reproductive toxicity in male albino rats. Olive leaf extract (OLE) exhibits potent antioxidant and antiapoptotic properties. Twenty-two mature male rats were divided into four groups: control (saline), CPF (9 mg/kg), OLE (150 mg/kg), and CPF + OLE. Treatment was administered orally for 80 days. The CPF significantly reduced serum sex hormones, sperm counts and motility, high oxidants (MDA), and depleted antioxidants (GSH, SOD, TAC) in the brain and testes homogenate; additionally, it decreased serum AChE and brain neurotransmitters, increased Bax, decreased Bcl-2, and boosted caspase-3 immune expression in neural and testicular cells. Immunological expression of Ki 67 in the cerebrum, cerebellum, choroid plexus, and hippocampus was reduced, and α-SMA in testicular tissue also decreased. Histopathological findings were consistent with the above impacts. OLE co-administration significantly normalized all these abnormalities. OLE showed significant protection against neural and reproductive damage caused by CPF.
Author Related Publications
Nashwa Ahmed Ali Mohamed Elshaer, "Crosstalk of EGFR signalling with Notch and Hippo pathways to regulate cell specification, migration and proliferation in cockroach panoistic ovaries", © 2015 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd, 2015
More
Nashwa Ahmed Ali Mohamed Elshaer, "The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica", royal society, 2016
More
Nashwa Ahmed Ali Mohamed Elshaer, "Eyes absent in the cockroach panoistic ovaries regulates proliferation and differentiation through ecdysone signalling", elsevier, 2020
More
Nashwa Ahmed Ali Mohamed Elshaer, "Biological silicon nanoparticles maximize the efficiency of nematicides against biotic stress induced by Meloidogyne incognita in eggplant", Elsevier, 2021
More
Nashwa Ahmed Ali Mohamed Elshaer, "Effects of rhizobacteria and seed oils as eco-friendly agents against Meloidogyne incognita infested pepper plants under greenhouse and repeated applications field conditions", Elsevier, 2022
More
Department Related Publications
Ibrahim Mohamed Kelany, "تجارب معملية على المستخلص المائى لبذور النيم", لايوجد, 1900
More
Mohammed Ahmed Ibrahim Yousef, "BIOLOGICAL CHARACTERISTICS AND PREDATION EFFICACY OF THE GREEN LACEWING, Chrysoperla carnea (STEPHENS) (NEUROPTERA: CHRYSOPIDAE) UNDER LABORATORY CONDITIONS", Zagazig J. Agric. Res., Vol. 42 No. (3) 2015, 2015
More
Elsayed Abdel Malek Elmadany Elsheikh, "Toxicity and biochemical effects of Neem Azal T/S, willow (Salix aegyptiaca L.) and Chasteberry (Vitex agnus-castus L.) on house fly, Musca domestica L. (Diptra : Muscidae)", Journal of Biopesticide, 2015
More
Mohammed Youssef Ibrahiem Hendawy, "Effect of processing on acetamiprid residues in eggplant fruits, Solanum melongena L.", academicjournals., 2013
More
Shadia Mostafa Taha Emara, "REPELLENCY AND FUMIGANT TOXICITY OF CLOVE AND SESAME OILS AGAINST AMERICAN COCKROACH: PERIPLANETA AMERICANA (L.)", أفريقيا, 2013
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف