Background: Recently performing laparoscopic right hemicolectomy, which is gaining wide acceptance for management of colon cancer, could be done through either intra-corporeal or extra-intracorporeal approaches. Both approaches have been used and a consensus is lacking. The aim of the current study was to compare the short-term and the long-term patients’ outcomes of performing laparoscopic right hemicolectomy that was performed through either extracorporeal or intracorporeal surgical approach in patients with right sided cancer colon. Methods: we analyzed data, retrospectively, from 120 colon cancer patients who were managed by laparoscopic right hemicolectomy by either intracorporeal or extracorporeal anastomoses. We compared between anastomoses regarding; demographic, clinicopathological, operative, perioperative, postoperative data, and data of disease recurrence, cancer specific death and survival rates. Results: The duration of the operative time was longer in the group of patients who underwent extracorporeal anastomosis than the group of patients who underwent intracorporeal anastomosis (p =0.003). We found a higher incidence of medical complications in the group of patients who underwent extracorporeal anastomosis than the group of patients who underwent intracorporeal anastomosis (p = 0.049). The group of patients who underwent intracorporeal anastomosis has a shorter hospital stay than the group of patients who underwent extracorporeal anastomosis (p=0.043). We found no significant differences between the two operated groups regarding; disease recurrence, progression, five-year disease free survival rate and overall survival rate. Conclusions: We showed that intracorporeal anastomosis has many advantages over the extracorporeal anastomosis as shorted operative time, less pain, faster recovery and a less liability to occurrence of medical complications, but it did not affect long-term patients’ oncologic outcomes as disease progression, recurrence and survival.