Nomophobia is discomfort, loss of rest and appearance of anxiety due to the unavailability of the smart phone that the student used to have with him all the time, and the fear to lose contact with the net or the information, and the fear to lose communication with others through the smart phone. The Current research aims at investigating the relationship among nomophobia, depression and alexithymia refer to non-clinical patients, and it is represented in the presence of difficulties in describing, identifying feelings, and orientation towards outward thinking. the descriptive approach is used. The sample of the research included (310) male and female students ranging from (15 to 18) years old. This sample was derived from three secondary schools in Tanta city. The researcher has applied Nomophobia questionnaire (Yildirim & Correia, 2015) as well as Toronto Alexithymia scale (TAS-20). After being edited to Arabic language In addition, Beck depression inventory (BDI) has been delivered after being translated by (Ghareeb, 1999). The results showed that there are positive correlation coefficients and a statistical significance among nomophobia, alexithymia and depression. The results of multiple stepwise regression analysis indicated that Nomophobia can be predicted through the total degrees of alexithymia and depression. The results were discussed and the researcher have formulated some recommendations and suggestions.