Heavy metals such as cadmium (Cd) pollute the environment. Heavy metal pollution endangers the Nile River since it serves as an irrigation and freshwater source for the cities and farms that line its banks. Water and sediment samples from the Nile River were tested for Cd content. In addition, a sequential experiment analytical method was performed to determine the metal’s relative mobility. According to the data, there is an average of 0.16 mg kg−1 of Cd in sediments. The BeniSuef water treatment plant and brick factory, the iron and steel factory of Helwan, the oil and detergent factory of Sohag, and the discharge of the cement factory in Samalut had the greatest concentration of Cd in their vicinity. According to the risk assessment code, there are four categories of Cd: residual (57.91%), acid-soluble (27.11%), reducible (11.84%), and oxidizable (3.14%). Bioavailable and mobile Cd levels in sediment and water were found in Beni Suef, Aswan; Helwan; Samalut; Sohag; and Helwan. Because the other metal is highly bioavailable, its concentration is not a risk factor at the Samalut station. Cd’s toxicity and bioaccumulation make it an extra hazard to aquatic animals and human life. There should be a deterministic approach to monitoring Cd near industrial sources.